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　　China Securities Network News (Wang Luo) started from the printing industry. Lingyun Guang has been deeply involved in the industrial machine vision industry for 20 years, and has expanded its applications to consumer electronics, new displays, new energy and other fields. Head enterprises in industries such as Apple, Huawei, Xiaomi, Foxconn, BOE and () are all important customers of Lingyun Guang.

　　On June 15th, Ling Yunguang (stock code: 688400) officially launched the inquiry offering, and will soon land in science and technology innovation board. The science and technology innovation board listing, Lingyun Guang plans to raise 1.5 billion yuan, and the fundraising direction is centered on the company’s vision planning. From industrial manufacturing to industrial intelligent manufacturing, machine vision is promising. The company will increase investment in technology research and development, continuously improve its platform-based capabilities, empower intelligent manufacturing, and help more industries achieve automation and intelligent development. The company’s development vision is to implant "eyes" and "brains" into machines and become a global leader in the fields of visual artificial intelligence and photoelectric information.

　　From agency to self-research, mastering the underlying core technology

　　According to the prospectus, Ling Yunguang was established in 2002, and started from the banknote printing industry, and carried out independent research and development through projects such as online detection of RMB gravure printing and large sheet detection; On the other hand, the agency business of foreign high-end visual devices is carried out. Since 2006, the company has successively entered the fields of printing and packaging, new display and consumer electronics, and further improved its independent research and development capabilities. At present, it has the research and development capabilities of advanced imaging, intelligent algorithms, intelligent software and automatic precision control, and independently developed core devices such as industrial cameras and light sources, which are applied to many industries.

　　The domestic machine vision started in the late 1990s. When Ling Yunguang entered this field 20 years ago, the domestic development and application were basically blank. The company started from scratch and gradually embarked on the road of independent research and development in the field of machine vision.

　　Ling Yunguang attached great importance to self-research of core technologies at the early stage of business development. During the period from 2002 to 2006, the company initially built a 100-person team with independent research and development capabilities of optical, mechanical, electrical, computing and software technologies, and started the research and development of independent software algorithms of VisionWARE. The technical accumulation in this period has created an insurmountable moat for the company’s competitors in a short period of time. Now the machine VisionWARE algorithm platform independently developed by the company has been iterated to version 5.0. Ling Yunguang is the first machine vision manufacturer in China to launch a purely independent bottom-level core algorithm library. The investment cycle of the bottom-level algorithm is quite long. It takes a lot of time and experience to optimize the core algorithm from the bottom, which makes it ahead of competitors in the same industry for about three to five years.

　　In addition, Ling Yunguang’s AI algorithm development based on deep learning, machine learning and knowledge map has also been at the forefront of the industry, forming an independent F.Brain intelligent algorithm platform, supporting factory-side and edge intelligence through edge computing, and supporting factory cloud intelligence through big data cloud computing technology. From the application point of view, the machine vision +AI technology is deeply combined to support industrial scenes.

　　It is understood that the algorithm library of the machine vision industry consists of open source vision algorithm libraries such as OpenCV, and third-party commercial payment algorithm libraries such as Vision Pro (cognex, USA), Halcon (German MVTec) and VisionWare (Ling Yunguang). Due to the long development cycle and large investment of algorithm library, companies in the industry usually develop their own application algorithms based on open source algorithm library, or independently develop and integrate with third parties, and few companies develop the underlying algorithms completely independently.

　　In addition to algorithms, Lingyun Guang has always been at the forefront of optical imaging technology, and has independently developed a series of visual core devices such as smart cameras and high-brightness special light sources. It has more than 70 patents in the optical field, and many solutions are the first to benchmark international and domestic machine vision friends, creating a brighter industrial "eye" competitiveness. At the same time, by investing in domestic CMOS sensor design company Changguang Chenxin and industrial lens professional company Hunan Changdao Optoelectronics, we will optimize the allocation of core resources and lay out the localization and autonomy of core technologies.

　　Form platform capability from system to equipment

　　After all, the banknote printing industry belongs to a special industry. After 2006, Ling Yunguang gradually expanded its business to printing and packaging, display screens, consumer electronics and other industries, and further integrated its research and development capabilities into platform-based capabilities of products and technologies, thus effectively supporting the company to achieve cross-industry development. In addition, the company began to expand its automation capability in 2016, and it took three years to gradually build automatic control technologies such as automatic assembly line and multi-axis precision manipulator.

　　Up to now, Lingyun Guang has four technical platforms, including advanced imaging, intelligent algorithm, intelligent software and intelligent automation, and comprehensive overall scheme design capability. It has 418 domestic patents and 208 software copyrights, which supports the company’s rapid expansion of downstream industries from printing to other fields, such as consumer electronics and new energy, and is also a technical base to support the company’s continuous leap-forward development in the future.

　　According to Ling Yunguang’s prospectus, up to now, the company has developed diversified intelligent visual equipment and innovative process solutions based on independent research and development of visual algorithms and AI algorithms for new display, consumer electronics, printing and packaging, new energy and other fields. Specific to the display field, the new display intelligent vision equipment products provided by Ling Yunguang can realize automatic and semi-automatic optical detection of small screen defects in TFT-LCD/OLED, covering the Cell process section and module process section, and support lighting detection when the screen is powered on and appearance detection when it is not powered on. The detection efficiency of the LCD lighting quality detector provided by it is more than 3 times that of manual work, which solves the problem of 2% low contrast stain defect detection, approaches the limit of human eyes, realizes high dynamic range detection, and has been popularized and applied in hundreds of sets in the industry.

　　Entering Apple’s industrial chain is a key milestone for Ling Yunguang, and it is also the inevitable result of technical capacity building. Five years ago, the company broke the situation that the high-end market of consumer electronic vision inspection was monopolized by foreign manufacturers such as cognex and Kearns for a long time, and became the Preferred Supplier in the field of machine vision certified by Apple, and began to provide configurable vision systems in batches.

　　"Hand", "Eye" and "Brain" cooperate to empower intelligent industrial production.

　　If configurable vision system products, such as machine vision algorithm platform developed by Ling Yunguang, can equip industrial machines with eyes and brains, then intelligent vision equipment is to implant muscles and limbs controlled by brains into the machines, thus realizing the precise control and execution of detection and production technology, and finally forming an intelligent production robot with the cooperation of hands, eyes and brains.

　　As the largest manufacturing country in the world, the penetration rate of domestic machine vision application is low, and there is still much room for growth, especially the aging population and the increase in labor costs, which also bring great demand to the machine vision industry.

　　From the demand of downstream customers, the epidemic situation in COVID-19 is complicated in recent years. Instead of reducing the budget for technology investment, downstream manufacturers have been further forced by the epidemic to strengthen their investment in industrial automation, digitalization and intelligence, and the cost reduction effect is very remarkable. In the future, the demand of downstream manufacturers for automation and intelligence is rigid and inevitable.

　　China market has become one of the fastest growing markets in the global machine vision market. According to the statistics of China Machine Vision Industry Alliance, the sales of machine vision industry in China increased from 10.18 billion yuan in 2018 to 14.42 billion yuan in 2020, with a compound growth rate of 19.02%. Thanks to the promotion of manufacturing automation and other factors, it is estimated that the sales of machine vision industry in China will increase at a compound growth rate of 27.15% from 2020 to 2023, and the sales will reach 29.6 billion yuan by 2023.

　　Under such opportunities, Lingyun Guang will continue to promote technological innovation in advanced optical imaging, software and algorithms, automation and other fields, and actively explore new application fields of industrial machine vision. At present, Ling Yunguang’s machine vision +AI products and services have achieved a high market share in consumer electronics, display panels, printing and packaging applications. According to the statistics of China Machine Vision Industry Alliance, in 2020, among the enterprises participating in the statistics (enterprises within the alliance), Lingyun Guang ranked first in the sales of machine vision industry in China.

　　According to the disclosure in the prospectus, the company is expanding its business to the field of new energy battery diaphragm detection, and has cooperated with customers such as Contemporary Amperex Technology Co., Limited. Focusing on the field of industrial manufacturing for 20 years, Lingyun Guang is expected to become the leader of industrial artificial intelligence, truly helping factories to improve quality, increase efficiency, reduce costs and reduce storage.

(Observer Network News/Lv Dong Editor/Yin Zhe)

On the evening of November 12th, vvild Xiao Ye officially issued a statement saying that it had completely stopped all self-operated sales on the Internet.

VVI ILD Xiao Ye said that Xiao Ye Science and Technology supported the relevant requirements of the State Administration of Markets and the State Tobacco Monopoly Bureau, and has taken the initiative to close online sales channels such as Tmall and JD.COM, deleted all online marketing content related to sales, and urged all non-self-operated social channels to stop online sales immediately.

VVI ILD Xiao Ye also said that it has strictly regulated the sales behavior of dealers when it goes online, and it is absolutely not allowed to recommend or sell e-cigarette products to minors.

Observer. com noticed on Tmall and JD.COM that keywords such as "Xiao Ye vvild" can no longer be searched.

Tmall screenshot

JD.COM screenshot

The following is the original statement of vvild Xiao Ye:

According to Xiao Ye official website, vvild, Xiao Ye is affiliated to Shenzhen Xiao Ye Technology Co., Ltd., and the founding team of Xiao Ye is from well-known brands such as Huawei and Hammer Technology. The team has rich experience in the design, production, marketing and sales of electronic consumer goods.

It is worth mentioning that at about 16: 00 on November 1 this year, the State Tobacco Monopoly Bureau and the State Administration of Market Supervision issued the Notice on Further Protecting Minors from E-cigarettes.

The notice pointed out that in order to further strengthen the protection of minors’ physical and mental health and prevent minors from buying and smoking e-cigarettes through the Internet, from the date of issuance of this notice,urgeE-cigarette production and sales enterprises or individuals timely close the e-cigarette Internet sales website or client;urgeThe e-commerce platform closes the e-cigarette shop in time and removes the e-cigarette products in time;urgeEnterprises or individuals producing and selling electronic cigarettes withdraw electronic cigarette advertisements published through the Internet.

Just about 20 minutes before the official announcement of the above notice, Luo Yonghao, the founder of Hammer Technology, just forwarded the news that "vvild Xiao Ye disposable atomized electronic cigarette" will be officially launched in Tmall and JD.COM on November 11th.

It is understood that e-cigarette is a "re-entrepreneurship" project of Luo Yonghao after he left the Nut mobile phone team. Just when the outside world thought that he would stick to making mobile phones, Luo Yonghao stepped down as the legal representative and chairman of Beijing Hammer Digital Technology Co., Ltd. in December 2018 and turned to enter the e-cigarette industry.

Screenshot from Weibo, Luo Yonghao

This article is an exclusive manuscript of Observer. It cannot be reproduced without authorization.

　　[Global Times special correspondent in the United States Zhang Sisi Global Times special correspondent Wang Cong] "Whether Assange can be free is widely regarded as a judgment of the Australian government’s influence on the Biden administration in the United States." The Associated Press reported on July 30th that since the Labor government came to power last year, Australia has been trying to persuade the United States to terminate the prosecution of Assange, the founder of Wikileaks. However, in the recent annual meeting between US Secretary of State Blinken and Australian Foreign Minister Huang Yingxian, Blinken said that Assange was accused of committing a "very serious criminal act".

　　The Associated Press reported that Blinken said during the talks that Assange was "suspected to be related to one of the most serious confidential information leaks in American history", and he understood Australia’s concerns and views on this matter, but urged Australia "as a friend, we should understand the concerns of the United States". Blinken also said that Assange’s "alleged acts may cause very serious harm to US national security" or even "life-threatening". Huang Yingxian responded that Australia has "made it clear publicly for many times" and that Assange’s case has been delayed for too long. Australia hopes that the United States can withdraw these allegations and settle the case as soon as possible.

　　In addition, the Australian Sydney Morning Herald quoted Huang Yingxian as saying that the United States had "inconsistent" attitudes towards Assange and Chelsea Manning, another protagonist of the "confidential document leak case" and a former American army intelligence analyst. Manning was arrested for leaking about 700,000 confidential military and diplomatic documents to Wikileaks and was sentenced to 35 years in prison in 2013. However, in January 2017, former US President Barack Obama commuted Manning’s sentence before leaving office, which led to her release in May of that year.

　　Assange has been detained in the high-security Belmarsh prison in south London since he was arrested by the British government from the Ecuadorian embassy in London in April 2019. In June, 2022, the British Home Secretary, Pruitty Patel, approved the request of the United States to extradite Assange. In July of the same year, Assange appealed the extradition order to the British High Court. According to the relevant laws of the United States, once Assange is extradited to the United States, he will be charged with espionage and improper use of computers in the United States, and he will face a maximum of 175 years in prison.

　　According to the Sydney Morning Herald, Blinken’s statement is the "sharpest and most detailed" comment made by Biden administration officials on Assange. Blinken’s remarks mean a "rare public disagreement" between the United States and Australia, and highlight that "the Albanese government faces an arduous task in persuading Biden’s government to stop pursuing Assange". The Guardian reported that Blinken’s defense of the American accusation against Assange would be regarded as "a heavy blow to the efforts of the international community to rescue Assange".

　　Assange, 52, was born in Australia and founded the Wikileaks website in 2006. In 2010, Wikileaks exposed a large number of American diplomatic cables and confidential documents of the US military during the Afghanistan War and the Iraq War, and exposed the war crimes of the US military. In 2019, after Assange was arrested in Britain, the United States immediately requested the extradition of Assange. Australian Prime Minister Albanese has repeatedly urged the US government to terminate the lawsuit against Assange. In May this year, Albanese said that he had expressed the Australian government’s position to the American and British governments that there was no benefit in continuing to imprison Assange.

　　"Assange’s supporters reacted angrily to Blinken’s remarks." "Australia is the closest ally of the United States, and Blinken needs to understand the overwhelming view of the Australian people, that is, it is fed up with Assange’s endless imprisonment," said Barnes, legal adviser of the Australian Assange supporters organization, according to the Sydney Morning Herald. Assange must be released immediately and be reunited with his family. "

At present, the customs clearance modes of cross-border e-commerce import business mainly include: express customs clearance, goods collection customs clearance and stock clearance.

What are the customs clearance modes for cross-border e-commerce?

(A) cross-border e-commerce import customs clearance mode-express customs clearance

After the order is confirmed, foreign suppliers will mail the goods directly from overseas to consumers through international express delivery. No customs documents.

Advantages: flexible, delivery only when there is business, no need to stock up in advance;

Disadvantages: When mixed with other express mail, the logistics clearance efficiency is low, and the cost will rise rapidly when the volume is large;

Suitable: the stage of less business volume and occasional sporadic orders.

(B) Cross-border e-commerce import customs clearance mode-goods collection customs clearance (orders first, then delivery)

Merchants package a number of sold goods in a unified way and transport them to domestic bonded warehouses through international logistics. E-commerce enterprises go through customs clearance procedures for each product. After being checked and released by the customs, e-commerce enterprises entrust domestic express delivery to consumers. Each order is accompanied by customs documents.

Advantages: flexibility, no need to prepare goods in advance, higher logistics clearance efficiency and lower overall logistics cost compared with express mail clearance.

Disadvantages: the packaging operation needs to be completed overseas, and the overseas operation cost is high, and the delivery from overseas takes a little longer.

Suitable for: at the stage of rapid growth of business volume, there are many orders every week. (3) Customs clearance mode of cross-border e-commerce import-stocking customs clearance (stocking first, then ordering)

Merchants stock overseas goods in batches to bonded warehouses under customs supervision. After consumers place orders, e-commerce enterprises go through customs clearance procedures for each product according to the orders, complete the veneer sheet and packaging in the bonded warehouses, and after being checked and released by the customs, e-commerce enterprises entrust domestic express delivery to consumers. Each order is accompanied by customs documents.

Advantages: bulk stocking to bonded warehouse in advance, the lowest international logistics cost, immediate delivery from bonded warehouse after orders are placed, the highest customs clearance efficiency, timely response to after-sales service requirements and the best user experience.

Disadvantages: the use of bonded warehouses has storage costs, and stocking will occupy funds.

Application: in the stage of large business scale and stable business volume. Purchase cost can be reduced by ordering in large quantities or in advance, and the international logistics cost can be reduced by gradually transitioning from air transportation to sea transportation, or the problem of capital occupation caused by stocking can be solved by pledge supervision financing.

(Source: Brother K chats with the sea)

CCTV News:Yesterday (October 24th), the data released by the National Bureau of Statistics showed that in the third quarter, China’s consumer market generally recovered steadily, and market sales maintained growth.

The data shows that in the first three quarters, the total retail sales of social consumer goods was 32,030.5 billion yuan, up 0.7% year-on-year, with a growth rate of 1-mdash; It accelerated by 0.2 percentage points in August. Quarterly, it increased by 3.5% in the third quarter, and the recovery in the third quarter was faster than that in the second quarter. In September, the total retail sales of social consumer goods increased by 2.5% year-on-year, of which the retail sales of commodities increased by 3%.

Guo Liyan, Director of Comprehensive Situation Research Office of China Macroeconomic Research Institute:At present, the domestic consumer market is also maintaining a stable trend, especially the potential of consumer demand such as online social zero, some emerging consumption and some green and low-carbon consumption is further released, which also drives the development trend of consumer market to stabilize and recover.

In addition, since the third quarter of this year, the Ministry of Commerce has continuously promoted the implementation of the policy of green smart home appliances going to the countryside, promoted the resumption and development of catering, accommodation and other industries, and created new consumption scenarios through digital empowerment and business travel and cultural integration, giving full play to the role of important platforms such as the international consumption season and stimulating consumption vitality. Beijing, Shanghai, Guizhou, Jiangxi and other places have also promoted the upgrading of consumer demand by issuing consumer vouchers and government subsidies.

1-mdash this year; In September, Shanghai won the title of the first store capital in the mainland with the number of 703 first stores. Recently, a number of first stores have just appeared in the waterfront core area of Shanghai Suhewan. This urban complex, which is incarnated from the historical protection buildings such as the Shanghai-style Shikumen building "Shenyuli", presents a rambling consumption experience after ten years of renovation. Among more than 140 brands, more than 70% are the first stores in China, the first in Shanghai and the first in the region.

Near the end of the year, with the opening of several heavy projects, Shanghai will continue to develop the starting economy, brand economy and tax-free economy, and cultivate a number of leading local brands and new online brands. It is expected that Shanghai will introduce more than 800 first stores this year. In Guizhou, since the third quarter of this year, a total of 113 million yuan of travel coupons have been issued to consumers inside and outside the province, which has driven the growth of travel consumption. In Zunyi City, 304 enterprises or merchants involved in tourism, catering, accommodation and retail have been included in the designated use points of cultural travel coupons.

Not long ago, Mr. Chen saw a novel thing on the Discovery Channel: Americans put a blocking bed at the end of some airport runways, which actually prevented planes from rushing off the runways. On the TV screen, the materials paved at the end of the runway successfully prevented a Boeing passenger plane from rushing out of the runway, which protected the plane and ensured the safety of passengers.

The technology presented in the picture is called Engineering Material Arresting System (EMAS), which has long been monopolized by foreign companies. On July 12th, 2012, EMAS, developed by China Civil Aviation Science and Technology Research Institute and with completely independent intellectual property rights, officially passed the qualification examination of Civil Aviation Administration of China and was approved for engineering application. This is an important progress made by China Civil Aviation in the research and development of major systems related to flight safety, and it is also the second EMAS in the world to be approved by government civil aviation authorities. The achievement of this achievement will greatly reduce the cost of installing the system in airports, thus promoting the effective improvement of safety and security capabilities of many plateau airports and airports with special terrain in China.

How to stop the plane from running off the runway?

With the rapid development of the world’s civil aviation industry, the number of take-off and landing flights has increased significantly, and the number of aircraft rushing off the runway has shown an upward trend. How to avoid serious accidents after the aircraft rushing off the runway has become an important issue for civil aviation safety. In order to solve this problem, as early as the 1960s, the British began to research and develop related technologies to stop planes that ran off the runway, but failed to form products for various reasons. By the 1980s, the Federal Aviation Administration (FAA) and an American company began to jointly develop the EMAS system.

In fact, EMAS is a kind of foam concrete with specific mechanical properties, which is laid on the ground of the runway extension line with a thickness of several tens of centimeters to form an arresting bed. Its width is consistent with the runway, and its length is between tens of meters and more than 100 meters. Once the plane rushes out of the runway, it enters it, and the foam concrete is crushed under the rolling of the wheels, so as to absorb the kinetic energy of the plane, and on the premise of ensuring the safety of the plane and the people on board, the plane will gradually slow down and finally stop in the arresting bed.

In 1990s, FAA approved the design method of EMAS system. In 1996, the first trial laying was carried out at Kennedy Airport in new york, and three planes were successfully stopped. Subsequently, the FAA issued a license for it and promoted it in civil airports in need in the United States. Up to now, 55 sets of EMAS systems have been laid in 35 civil airports in the United States, and 8 planes have been successfully stopped. At the same time, the United States promotes the EMAS system on a global scale. In recent years, the system has been installed at Jiuzhai Huanglong Airport in Sichuan and Songshan Airport in Taiwan.

Can solve the problem of running off the runway.

Sichuan Jiuzhai Huanglong Airport was built by cutting mountains, surrounded by mountains on three sides. Due to the influence of complex terrain and high altitude, pilots often feel that the runway is short during the flight mission of Jiuzhai Huanglong Airport, especially in rainy and snowy weather. Once the plane lands and stops taking off, there will be back spraying, brake failure or rushing off the runway, and the consequences will be unimaginable. Therefore, in 2006, when Jiuzhai Huanglong Airport carried out the second phase expansion project, two sets of EMAS systems were installed at the north and south ends of the runway respectively.

In China, a considerable number of airports are built by cutting mountains, commonly known as "desktop airports". Although these airports have established runway-end safety zones according to the standards, there are often steep slopes or cliffs outside the safety zones. Once the plane rushes out of the runway-end safety zone, the tragedy of plane crash and death will inevitably be staged. In addition, some airports in Linjiang, Linhai and residential areas also have such problems.

With the rapid development of civil aviation in China, the number of flights has increased dramatically. In order to maintain the past safety level, we need updated safety measures. According to the statistics of ICAO, the number of runway accidents in the world ranks first in the statistics of civil aircraft accident types. In recent years, the number of incidents of civil aviation rushing off the runway in China also ranks first in the statistics of serious accident symptoms of civil aircraft. It can be seen that the installation of EMAS system in the airport where the safety zone at the runway end is not long enough can solve the problem of the plane rushing off the runway and obviously improve the safe operation level.

Technical problems of

Before the EMAS developed by the China Academy of Civil Aviation Science and Technology was approved by the Civil Aviation Administration of China, there were no similar products in China. If we want to install it in our airports, we need to face three problems: high product price, long transportation distance and difficult system maintenance.

It is reported that in 2010, Taiwan Songshan Airport plans to lay a set of this system, with a budget as high as NT$ 430 million. Compared with 2006, when the system was laid at Jiuzhai Huanglong Airport in Sichuan, the price has increased significantly. Such a high cost, even if the government gives most subsidies, it is difficult for small and medium-sized airports in China that need to install EMAS system most.

China needs its own EMAS system! In 2010, under the direction of Li Jian, deputy director of the Civil Aviation Administration, the Academy of Aeronautics and Astronautics organized a research and development team headed by its main leaders and attended by dozens of scientific research backbones, and relevant units in the United Nations invested tens of millions of yuan. After more than two years, the technical problems of material production and system design methods have been overcome. In order to effectively verify the performance of the product and the safety of the system, the Institute of Aeronautics and Astronautics designed and built a special test bench, conducted dozens of tests on the process of wheel rolling materials, and obtained a lot of valuable data, and finally established a set of perfect simulation calculation model and design method for the blocking process. The Academy of Aeronautics and Astronautics also specially purchased a Boeing 737 aircraft from Air China. Since the fourth quarter of 2011, it has carried out six large-scale real aircraft verification tests using the second runway of Tianjin Airport. The test results show that the EMAS system developed by the Institute of Aeronautics and Astronautics has an effective blocking effect and can ensure the safety of the aircraft and the crew.

Development prospect of

"For China’s civil aviation, the EMAS project is a brand-new and groundbreaking project, and only the United States has mastered this technology in the world. We don’t have any experience to learn from. Doing this project well is of great significance for China civil aviation to export standards to the international civil aviation community, to enhance the international status of China civil aviation, to enhance the safety margin of complex airports, and to build a strong civil aviation country. " Li Jian, deputy director of CAAC, has repeatedly emphasized the importance of China Civil Aviation in developing its own EMAS system.

The responsible person of Academy of Aeronautics and Astronautics (Beijing) Science and Technology Development Co., Ltd. revealed to the reporter that the successful research and development of domestic EMAS system has greatly reduced the laying cost, and provided reasonable engineering solutions for many plateau airports, airports with complex terrain and other airports that are difficult to extend the runway safety zone for special reasons. It has a very broad market prospect. Tengchong Airport has decided to install EMAS system, and many airports at home and abroad have also shown strong interest in this product. "We have more than 10,000 square meters of production workshop in Tianjin Airport Economic Zone, which can meet the environmental requirements for the production and maintenance of blocking materials, and can ensure the stability of material performance, and can produce one set of materials required for EMAS system every month."

This year, ICAO will put forward the standard of increasing the length of the safety zone at the runway end in the "International Standards and Recommended Measures" to reduce the serious flight safety accidents caused by running off the runway. However, due to geographical or other environmental constraints, many airports are difficult to meet the new requirements for the length of runway safety zone. EMAS has been written into Article 3.5.5 of Airport Design and Operation, Volume I, Annex 14 of ICAO Convention on International Civil Aviation, which has become an internationally accepted equivalent safety measure.

It is understood that although the price of domestic EMAS system has dropped significantly compared with similar products abroad, it is also a huge expense for many airports, especially small and medium-sized airports. In view of the purpose of laying EMAS system to improve the safety of airport operation, CAAC is working on formulating relevant subsidy policies to support the popularization and application of EMAS system.

In today’s digital era, electronic invoices have become a common form of bills in economic activities. It is very important for individuals and enterprises to master the relevant knowledge of electronic invoices.

To master the relevant knowledge of electronic invoices, you can first obtain information through official channels. The official website of the tax department is an important source of information, which will contain detailed contents such as policy interpretation, issuance process, reimbursement regulations and so on. In addition, you can also pay attention to the official WeChat official account of the tax department and get the latest policy trends and operational guidelines in time. At the same time, corporate financial personnel can also participate in training courses organized by tax authorities to systematically learn the relevant knowledge of electronic invoices.

For individuals, when they come into contact with electronic invoices in their daily lives, they can consult the merchants about relevant issues, and know how to issue electronic invoices and how to obtain them. You can also search related knowledge articles and videos through the Internet to learn more about the use of electronic invoices and matters needing attention.

Electronic invoice has its unique format and characteristics. From the format, the common electronic invoice formats are PDF, OFD and so on. PDF format is a common one, it has good compatibility, and most devices and software can be opened for viewing. OFD format is a format of layout document independently developed by China, which has the advantages of high security and strong traceability.

The characteristics of electronic invoices are very remarkable. First, it is convenient to issue. Compared with traditional paper invoices, electronic invoices can be generated quickly through the system without filling in a lot of information manually, which greatly improves the billing efficiency. Second, it is convenient to store. Electronic invoices exist in the form of electronic data, which can be stored in computers, mobile phones and other devices without fear of loss or damage. Third, environmental protection and energy saving. Electronic invoice reduces the use of paper and conforms to the concept of green development. Fourth, the inspection is easy. Consumers and enterprises can quickly and accurately check the authenticity of electronic invoices through the official inspection platform of the tax department.

The following is a comparison table between electronic invoices and traditional paper invoices:

In a word, knowing how to acquire knowledge, format and characteristics of electronic invoices will help us to use electronic invoices more efficiently and conveniently in economic activities and adapt to the development trend of digital economy.

　　● With the increasing popularity of self-help outdoor tourism, outdoor clubs, donkey friends clubs and go on road trip clubs frequently publish tourism products illegally through WeChat groups or QQ groups, publicize tourism routes, and receive citizens or donkey friends to travel.

　　● According to the relevant provisions of the Tourism Law, it is illegal for non-tourism enterprises and individuals to organize tourism activities by themselves.

　　● To completely eradicate the chaos of compulsory consumption of low-priced groups, we should rely on the law, increase punishment measures, and increase illegal costs and rights protection benefits.

　　□ Our reporter Zhao Li

　　"Since you have chosen a group with shopping links, you need to spend. What was your attitude towards me in the shop today? They’re all fighting guerrillas in there! Now get off and go to the store, and spend 20,000 yuan an hour … …” These words came from a female tour guide in Guilin.

　　This female tour guide brought a group organized by a beauty brand. According to tourists, "Give a product gift of 598 yuan to the travel agency", and you can go to Guilin from Hunan for free. On the last day of the trip, due to the high consumption of jade shops, the consumption of tourists did not meet the "psychological expectation" of the tour guide, so the above scene appeared.

　　After this compulsory consumption incident was exposed, the "low-priced group" once again attracted attention.

　　With the increasing popularity of self-help outdoor tourism, it is not uncommon for outdoor clubs, donkey friends clubs, go on road trip clubs, health care products sales enterprises and some training institutions to illegally publish tourism products, publicize tourism routes and receive citizens or donkey friends to travel through WeChat groups and QQ groups. According to the relevant provisions of the Tourism Law, it is illegal for non-tourism enterprises and individuals to organize tourism activities by themselves. However, according to the disclosure of relevant departments, many tourism activities attract consumers to join the group with "low-cost group tours" or even "zero group tours".

　　Through unannounced visits to such organizations that operate travel agencies without travel qualifications, the "Legal Daily" reporter found that many low-priced groups hide many tricks.

　　Ostensibly claiming not to be profitable.

　　In fact, hidden invisible consumption.

　　Recently, the reporter found a large number of QQ groups of related organizations through online search, and the format of group names is simple and consistent: ×× Outdoor Club. The reporter tried to apply to join the QQ group of these outdoor clubs as an outdoor sports enthusiast, but the pass rate was extremely low. Many applications for joining the group are "sinking into the sea" after they are issued. Some organizations directly rejected the reporter’s application for joining the group. For example, the ×× Shanshui Outdoor Club refused on the grounds that it was not introduced by acquaintances in the group after the reporter repeatedly applied for joining the group.

　　After many attempts, the reporter finally entered the individual group chat as an ordinary tourist, but after joining the group, the relevant responsible persons of these organizations will know the information of the new group users, such as "Who introduced them", "Where did they come from" and "What activities have they participated in before".

　　At present, the QQ group of "Beijing XX Outdoor Club" has 1436 people, and it promotes itself as an outdoor adventure club with the theme of mountaineering, hiking, camping, grassland riding, desert crossing, forest adventure, seaside swimming, photography, skiing, food, singing and making friends. The outdoor activities of this club are rich and varied, and most of them are short-lived, generally divided into one-day activities and two-day activities. The prices of short-term activities are generally low. Many one-day activities cost less than 100 yuan, and some two-day activities cost around 300 yuan. Take the one-day tour of Kingfisher Valley (located in Yanqing, Beijing) as an example. The activity cost is 65 yuan/person, including car charter, expressway fee, master fee and outdoor insurance. The activity was held on June 15th. By 15:30 on June 14th, more than 50 people had signed up.

　　The person in charge of the club explained to the reporter: "The expenses incurred by the activity are all AA system, without any additional benefits."

　　Two years ago, Ms. Wang, a citizen of Beijing, was dragged into an outdoor tour group, which published many low-priced tour routes. "People who organize tours say that if they don’t make money, they just organize everyone to go out to play." But Ms. Wang found that they "have not earned less money."

　　She once took part in a trip to Zhangjiakou, the cost was not enough for 300 yuan, but after getting on the bus, the hidden cost began. The organizer charged each tourist 50 yuan’s hard work and each tourist had to pay 10 yuan’s tea fee after the meal.

　　"Without a formal contract, it is too informal for such a tour group to transfer money through WeChat or pay by punching in." Ms. Wang said.

　　Some insiders also revealed to reporters that some outdoor clubs often attract friends to travel under the banner of non-profit, and the relevant personnel of the club make profits through the price difference. Because outdoor clubs don’t need to pay deposits and taxes like travel agencies, the operation of outdoor clubs is almost "zero cost".

　　The reporter interviewed Mr. Zhang, a staff member of a scenic spot who is in charge of receiving these clubs. He said: "The profits of related expenses can basically be divided into four or six with the organizers, and the commissions taken by general travel agencies or tour leaders are more."

　　The promoter declares that he is not responsible.

　　Tourists face greater risks.

　　Another "Beijing Lvyou ××" QQ group information shows that it was founded on October 23, 2015. At present, it has 2,862 members and has organized 44 activities. The organizer is "Beijing× Wolf Outdoor". The activity destinations are nearly Shuanglong Gorge, Pofengling and Dongling Mountain in the suburbs of Beijing, and as far away as Wuyuan, Dunhuang and Mohe.

　　According to the information of official website in Beijing × Wolf Outdoor, this organization is "dedicated to the tent rental industry in Beijing (Tianjin)", and its business scope mainly includes various outdoor goods rental businesses such as Beijing (Tianjin) camping tent rental, cotton sleeping bag rental, down sleeping bag rental, walkie-talkie rental and mountaineering bag rental.

　　The official website page of Beijing × Wolf Outdoor has also set up a column of "Journey Friends Activities". Open this page, which shows 70 pieces of relevant travel information released by this organization from June 6, 2017 to October 24, 2018. The reporter opened several links, most of which are related introductions such as tourist routes, itinerary planning and cost range, and occasionally a "disclaimer" is attached to the introduction. Disclaimer said: The initiator of the activity is only the contact person of the activity, and may not have participated in the training of outdoor leaders and field rescue. Although it is obligatory to help every participant, the initiator and leader of the activity are not responsible for any damage and consequences caused by participating in the activity — — Sign up voluntarily at your own risk.

　　Such a disclaimer can also be found in the details of the activities of the "Beijing donkey friends ××" QQ group.

　　The reporter found that the Mountain X Outdoor Club has also organized outdoor travel activities many times. According to a tweet from its WeChat WeChat official account on June 13th, the length of a seven-day trip is around 3,000 yuan per person. The travel routes include Jiaju Tibetan Village, Hailuogou Glacier, Daocheng Aden, Siguniang Mountain and other popular tourist attractions. The expenses include transportation (driver’s accommodation), accommodation (7 nights), tickets (Siguniang Mountain Shuangqiaogou, Jiaju Tibetan Village, Aden Scenic Area, Hailuogou), meals (breakfast in Danba), tour leader service and insurance. At the same time, it is stated that this line only buys travel accident insurance for players, excluding illness insurance and financial insurance. During the activity, if the financial loss occurs, it shall be borne by the players themselves; If financial losses are caused by personal reasons and need to be handled by themselves, a "departure agreement" needs to be signed.

　　Another go on road trip club, "X Ant go on road trip Club", also indicated similar terms in a go on road trip route push on June 14th. There is only a 500,000 yuan personal accident insurance in the travel expenses, and there is nothing else.

　　The leader of "Beijing × Star Club" told reporters that the price given by his club was "more cost-effective than the travel agency" and an extra accident insurance would be given. When the reporter asked whether to sign the relevant responsibility contract, the team leader replied: "Without signing the contract, the activities are voluntary."

　　Free travel has become a new trick

　　Force shopping to set a trap

　　It is worth noting that related disputes occur frequently.

　　In April 2017, Tian Congxin, an outdoor travel enthusiast, sued the organizer of the WeChat group tour and lost the case. The lawsuit originated in the summer of 2016. He and his friends joined the WeChat group of Happy Friends’ self-help tour and drifted to Daqinggou, Inner Mongolia. During the drifting, he accidentally caused an acute compression fracture of the lumbar spine. When he claimed compensation from the tourism organizer, he was rejected and sued the court. The court ruled that the organizer did not aim at profit, and because Tian Congxin was injured in the wrong sitting position, he took full responsibility.

　　On November 22nd, 2014, Zhang Bingyu followed the coaches of Qingdao Qianli Sports and Leisure Club Co., Ltd. to Jiuxian Mountain for altitude downhill outward bound training. During the descent, the protective rope was untied, and Zhang Bingyu fell from a height of about 30 meters above the ground and died. Yu, an employee of Qianli Sports Company, is the leader of this outward bound training. He knows Cao, whose net name is Mumu, from the outdoor sports group, who was temporarily hired by the company as the outdoor coach of this activity. According to the verdict, both Yu and Cao claimed that they did not have the qualification certificate to engage in downhill activities.

　　Organizations and individuals without tourism qualifications like this often offer various low-cost tours when operating travel agency business.

　　According to a Beijing resident who didn’t want to be named, his parents participated in a low-cost tour organized by the "outdoor donkey friends group" WeChat group. "Everyone has a one-day tour in 50 yuan and Yixing Zhuhai. My parents gather at 6: 30 in the morning and come back with big bags at 6: 00 in the evening. Bamboo shoots, bamboo chopping boards, activated carbon balls, dish towels, etc., spend hundreds of dollars and buy a bunch of useless things. "

　　The reporter interviewed Mr. Zhang, who used to be a tour guide. Mr. Zhang said: "In the tourism industry, low-cost groups basically imply consumption content, which is a default rule in the industry. But if you pay enough money reasonably, there may be only some slight guidance and no compulsory consumption. "

　　Ma Aiping, a professor at beijing international studies university Tourism Management College, thinks that the tour fee for four days and five nights is 598 yuan. If this fee includes food, accommodation and transportation, the price is obviously low, so travel itinerary includes three shopping items.

　　Liu Simin, director of the Tourism Research Institute of the Cultural and Creative Industry Research Center of Beijing Foreign Studies University, believes that there may be many reasons for being lower than the market price and operating cost, but if there are obvious shopping arrangements in the itinerary, it can basically be judged as unreasonable low-cost travel.

　　In 2017, the National Development and Reform Commission, in conjunction with the public security, industry and commerce, price and other departments, continued to carry out a number of actions to comprehensively rectify the order of the national tourism market, and seriously investigated and dealt with illegal acts such as "unreasonably low-cost travel" and "illegally operating travel agency business", and filed 2,595 cases, fined and confiscated illegal income of 33.26 million yuan, and revoked 45 business licenses.

　　Since then, although the related problems of some travel agencies have been contained and supervised to a certain extent, some organizations and individuals who operate travel agencies without tourism qualifications have begun to "move". There are also companies tying health care products during the "zero tour fee" tour.

　　Take Jiufang Joy as an example. This company is not qualified to organize tourism. In August 2018, a fire broke out in Beilong Hot Spring Leisure Hotel in Harbin, Heilongjiang, causing 20 deaths and 23 injuries. According to media reports, Jiufang Joy mainly sells health care products to middle-aged and elderly people, and customers with large consumption can get travel opportunities rewarded by enterprises.

　　According to the disclosure of relevant departments in Beijing, many tourism activities use "zero tour fee" as bait to attract the elderly to join the group, which hides multiple risks. Law enforcement officials of relevant departments in Beijing said that low-cost tours under the guise of "free tours" and "zero tour fees" are becoming more and more hidden, and the elderly often become the "hardest hit areas" for being deceived.

　　According to law enforcement officials, at present, "buying health care products for travel" and "buying wealth management for free travel" organized in the form of companies have become new tricks of criminals, and even some companies cheat in the name of recruiting "tourism experiencers", and applicants encounter compulsory shopping traps when traveling.

　　"WeChat friends circle, clubs, motorists’ clubs and other spontaneous group trips are often personal agreements, and there is no business license. Many irregular behaviors cannot be defined and are in a blind spot of supervision. This kind of tourism behavior is more prone to problems, ‘ Black tour guide ’ The phenomenon of slaughtering customers is even more difficult to detect, which brings difficulties to tourism law enforcement and evidence collection. " Beijing lawyer Liu Chengxian told reporters.　　

Google’s strongest AI model, which has attracted much attention and is considered by the industry to be the most likely to beat GPT-4, has finally appeared!

On December 6th, US Western Time, Google CEO Sundar Pichai and DeepMind Director Demis Hassabis jointly announced the official launch of Gemini 1.0 in official website.

Gemini is jointly created by several Alphabet teams such as Google Research and DeepMind. As a new powerful multi-modal artificial intelligence model, it can induce, understand, operate and combine different types of information. It can not only process text, images, video and audio, but also complete complex tasks in mathematics, physics and other scientific fields, and can understand and generate high-quality codes in various programming languages.

Pichai described Gemini as "our largest and most powerful AI model to date" and said that it has shown the most advanced performance in many leading benchmarks. "The first generation of Gemini 1.0 was optimized for different sizes, namely: Ultra, Pro and Nano. These are the first models to enter the Gemini era and the first realization of our vision when we established Google DeepMind earlier this year. "

At the Google I/O conference in May this year, Pichai spoiled the news that Google was developing Gemini. It is described as the "Next Generation Multi-modal Intelligent Network", which is designed for API integration. It is said that it has trillions of parameters like GPT-4, but its computing power is five times that of GPT-4, and it can perform more complex and diverse tasks.

To this end, Google also merged its two strongest artificial intelligence laboratories: Google Brain and DeepMind, led by Demis Hassabis, the former CEO of DeepMind, and invested hundreds of millions of dollars in research and development of Gemini.

Even sergey brin, the co-founder of Google, who has resigned for four years, has returned to the office of Mountain View in Silicon Valley to participate in the Gemini decision-making and join the LLM scuffle.

But just last week, The Information quoted people familiar with the matter as saying that Pichai recently silently canceled a series of Gemini public appearances that should have been held in California, new york and Washington, D.C., because it was found to be "unreliable in handling some non-English queries", which cast a gray color on the product launch process.

Perhaps to consolidate market confidence, early this morning, Gemini 1.0 suddenly made its grand debut, appearing in the public’s field of vision and quickly occupying the front pages of major scientific and technological media.

So, what is the strongest artificial intelligence model that Google is betting on the whole army?

Hassabis, head of DeepMind, called Gemini their most flexible model, which can run efficiently on all kinds of devices from data centers to mobile devices.

In order to achieve this extensibility, Gemini 1.0 has designed three versions with different functions and sizes:

Gemini Nano —The most efficient model on the end-side equipment. Designed for smart phones, it can perform efficient AI processing tasks without connecting to an external server. Now it has been integrated into Pixel 8 Pro, which can support the function of "summarizing text" in recording applications and the function of "intelligent reply" in Gboard. Starting with WhatsApp, it will be extended to more applications next year.

Gemini Pro —The best model for various tasks running in Google data center. Support the latest version of the AI chat robot Bard from today. It can respond quickly and understand complex queries, which is the biggest upgrade since Bard was introduced. At present, it provides English services to more than 170 countries and regions, and plans to support new languages and regions in the coming months, and apply them to more Google products such as search, advertising, Chrome and Duet AI.

Gemini Ultra -The largest and most powerful model, dedicated to highly complex tasks, will be provided to developers and enterprise customers early next year after completing the current testing phase. At that time, an updated version of Bard Advanced based on Gemini Ultra will be launched.

In terms of model architecture, Gemini still uses Transformer architecture, adopts an efficient attention mechanism, and supports the context length of 32k.

Google confidently said that after rigorous testing and performance evaluation of the Gemini model, from natural image, audio and video understanding to mathematical reasoning,Among the 32 academic benchmarks widely used in the research and development of large-scale language models, the performance of Gemini Ultra has exceeded the most advanced level represented by ChatGPT at present.. Before the release of Gemini, Google conducted a series of tests to evaluate it with standard industry indicators.

In the MMLU test, the score rate of Gemini Ultra is 90.0%, which is higher than that of GPT-4 (86.4%), making it the first model to surpass the performance of human experts. The MMLU test covers 57 subjects, including mathematics, physics, history, law, medicine and ethics, and aims to evaluate the model’s understanding and problem-solving ability in the global knowledge field.

In Reasoning, Math and Code, except HellaSwag, which lags behind GPT-4 by 87.8%, others include challenging math problems such as multi-step reasoning, algebra/geometry/pre-calculus and so on.

In terms of multimodal capability, Gemini Ultra achieved a SOTA score of 59.4% in the new MMMU benchmark test, which exceeded the 56.8% of the multimodal version GPT-4V of OpenAI. This benchmark test spans many different fields and requires precise reasoning for many tasks.

In the image benchmark test, even without the assistance of Object Character Recognition (OCR) system, the performance of Gemini Ultra is better than all previous models only by analyzing pixel information. In audio testing, the scores of automatic speech recognition and automatic speech translation of Gemini are higher than those of Whisper system connected to GPT-4.

Hassabis said that this highlights the superiority of Gemini’s native multimodal. Up to now, the usual way to create multi-modal models is to train individual components of different modes independently, and then splice them together to try to simulate some functions.

Although such models can sometimes effectively perform specific tasks such as describing pictures, they often perform poorly in more conceptual and complex reasoning.

Gemini was originally designed in a native multi-modal way, and was pre-trained in different modes from the beginning using TPUs v4 and v5e chips designed by Google.. Then it is fine-tuned with more additional multimodal data to improve its performance.

This method enables Gemini to understand and reason all kinds of input content more naturally in the initial stage, and its ability in almost all fields has reached an unprecedented advanced level.

First of all, Gemini has complex multi-modal reasoning ability, which can help to understand complex written and visual information and discover indistinguishable knowledge content in massive data.

For example, it is instructed to filter irrelevant papers through the natural language prompt, or extract key data through reading. With a lunch break, Gemini can help you extract 250 document points from 200,000 papers, and further transform the data into any required chart form. This will greatly help to achieve innovative breakthroughs in science, finance and other fields at a digital speed.

The trained Gemini can obviously recognize and understand text, image and audio data at the same time, better understand subtle information and answer questions related to complex topics. This makes it especially good at explaining reasoning in subjects such as mathematics and physics. In the example, the staff showed that Gemini can check handwriting physical mistakes and explain the correct way.

In order to show the multimodal capabilities of Gemini more intuitively, Brother Chai released a video in X, saying that "the best way to understand the amazing potential capabilities of Gemini is to look at their practical applications".

In the video, Gemini taught the staff the pronunciation of "duck" in Mandarin according to the instructions, and also explained the Chinese tone.

The staff also gave Gemini a demonstration of interaction only in Chinese. By asking about the indoor light in a picture, Gemini is asked to give the orientation of the apartment in use. Gemini answers in Chinese and guesses that the room faces south. Circle a plant in the photo and ask what kind of lighting it needs. gemini then explains the plant species and lighting requirements. The whole process is as smooth as the mother tongue, which shows that Gemini is outstanding in multilingual environment, which is no less than GPT-4.

In addition, Gemini can understand, interpret and generate high-quality codes of the most popular programming languages in the world, such as Python, Java, C++ and Go. The ability to achieve cross-language work and handle complex information makes it one of the world’s leading basic coding models, helping programmers to use the powerful AI model as a collaborative tool to design applications.

For developers, starting from December 13th, Gemini Pro can be obtained through the Gemini API in Google AI Studio or Google Cloud Vertex AI. Android developers can also use Gemini Nano, the most efficient model for end-to-end tasks, through AICore.

Looking back on the development of Google’s big model all the way, compared with the continuous and rapid update of OpenAI’s "Wang Fried", Microsoft always seems to be one step behind when it integrates various AI functions of GPT into core products and pushes them to customers. When Bard, a chat robot, was released in February this year, it got off to a bad start, and the market value evaporated by 100 billion dollars overnight with a factual error. Benchmarking Microsoft Copilot’s Duet AI work suite, the market response was moderate, and the financial performance of cloud services also lost to Microsoft.

Especially after the internal friction caused by the reorganization of Brain and DeepMind teams and the loss of senior talents to OpenAI, Google’s AI battle is even more exhausted.

However, this is, after all, an AI pioneer who contributed to Transformer’s pioneering masterpiece Attention is all you need and the landmark artificial intelligence program AlphaGo, and inspired the subsequent development of many large models including ChatGPT. No matter from the technical genes, training data, capital and infrastructure, it should have one of the best strengths.

The release of Gemini is regarded by Google as the most critical technological innovation in the past decade. Can it make Google rally, beat OpenAI and regain the throne of the big model stadium?

Will the AI competition pattern be reshaped after Genmini Ultra comes out next year?

And, has everyone tried the new Google Bard? How do you feel?

Welcome to leave a message to share, or join the group to discuss with us!

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guide　language

The treatment scheme of herpes zoster can be roughly divided into traditional Chinese medicine therapy and western medicine therapy. Today, we will learn the western medicine therapy recommended by the guide.

Therapeutic goal of herpes zoster

Relieve acute pain; Shorten the duration of skin lesions; Prevent the spread of skin lesions; Prevent or reduce complications.

First, antiviral drugs

Commonly used drugs in clinical treatment of herpes zoster can effectively shorten the course of disease, accelerate the healing of rash, reduce the formation of new rash and reduce the spread of virus to internal organs. It should be used within 72 hours after the eruption, so as to quickly reach and maintain the effective concentration and obtain the best therapeutic effect. At present, the approved systemic antiviral drugs include acyclovir, valaciclovir, famciclovir, bromovudine and foscarnet sodium.

acyclovir

Function characteristics:

Acyclovir triphosphate is produced by phosphorylation of viral thymidine kinase in infected cells, which can inhibit viral DNA polymerase and stop the extension of viral DNA chain.

　 Usage:

(1) Oral administration: 400-800 mg/time, 5 times/day, for 7 days;

(2) Intravenous drip: 5 ~ 10 mg/kg for patients with immune impairment or serious nervous system diseases, once every 8 hours, with a course of 7 days.　

Precautions:

Patients should drink plenty of water during the administration of acyclovir to prevent acyclovir from precipitating in renal tubules and damaging renal function.

Valaciclovir

Function characteristics:

The prodrug of acyclovir is quickly absorbed by oral administration and quickly converted into acyclovir in gastrointestinal tract and liver, and its bioavailability is 3~5 times that of acyclovir.

　 Usage:

Oral administration: 300 ~ 1000 mg/time, 3 times/day, for 7 days.

Fanciclovir

Function characteristics:

The prodrug of penciclovir is rapidly converted into penciclovir after oral administration, and maintains a long half-life in cells. The mechanism of action is the same as that of acyclovir, the bioavailability is higher than that of acyclovir, and the frequency and dosage of administration are lower than that of acyclovir.

　 Usage:

Oral administration: 250 ~ 500mg/time, 3 times/day, for 7 days.

brivudine tablets

Function characteristics:

The antiviral effect is highly selective, and the process of inhibiting virus replication is only carried out in virus-infected cells.　

Usage:

Oral administration: 125mg／/day, l times/day, for 7 days.

Sodium foscarnet

Function characteristics:

Blocking the phosphate binding site of viral DNA polymerase in a non-competitive way, thus showing antiviral activity.

　 Usage:

Intravenous drip: 40 mg/kg each time, once every 8 hours.

Note meaning　

Patients with renal insufficiency should reduce the dosage accordingly;

If renal function continues to decline, acyclovir should be stopped immediately and famciclovir or other antiviral drugs should be used to continue treatment;

For patients suspected of renal insufficiency, creatinine level should be detected before initial administration (creatinine level is not required for bromovudine).

Second, analgesics

Mild to moderate pain:Acetaminophen and tramadol can be selected;　

Moderate and severe pain:

1. Opioid drugs, such as morphine or oxycodone;

2. Drugs for the treatment of neuropathic pain, such as calcium channel regulator gabapentin and pregabalin, in addition to amitriptyline and 5% lidocaine patch. Severe acute pain during herpes zoster is a risk factor for post-herpetic neuralgia (PHN). Combined with calcium channel regulator can not only effectively relieve pain, but also reduce the occurrence of PHN. Studies have shown that early use of pregabalin can significantly reduce the pain score of herpes zoster, especially within 7 days of herpes occurrence, which can significantly reduce the incidence of PHN. The pain of elderly patients with herpes zoster is more common and severe, which seriously affects all aspects of life, such as anxiety, disorder and inability to work or live normally. Studies have shown that pregabalin combined with oxycodone can not only further reduce the incidence of PHN, but also improve the daily activities and sleep of patients and improve their quality of life.

Third, glucocorticoid

At present, there is still controversy about whether to use glucocorticoid to treat herpes zoster.

It is generally believed that systematic application of glucocorticoid in the early stage of acute onset of herpes zoster and gradual decrease can inhibit the inflammatory process, shorten the duration of acute pain and the healing time of skin lesions, but it is ineffective for the pain with PHN.　

Recommended dose:The initial dosage of prednisone is 30~40 mg／/day, which is taken orally and gradually reduced, and the course of treatment is 1~2 weeks.

　Fourth, neurotrophic drugs

It is also helpful to relieve neuroinflammation and neuralgia. Commonly used drugs include mecobalamin, vitamin B1 and vitamin B12, etc., which are taken orally or injected intramuscularly.

Five, topical drugs

Mainly dry and anti-inflammatory.　

Blister fluid is not broken:Calamine lotion, acyclovir cream or penciclovir cream can be used externally.　

After herpes is broken:

3% boric acid solution wet compress;

1: 5000 furacilin solution wet compress;

0.5% neomycin ointment for external use;

2% mupirocin ointment.　

Ophthalmic herpes:3% Acyclovir Eye Ointment and Iodine Eye Drops for External Use.

References: [1] Herpes Zoster Expert Consensus Working Group. Herpes Zoster Expert Consensus in China [J]. Chinese Journal of Dermatology .2018,51 (6): 403-406.

Laiyuan/Yunque